Wu Zengbao, Zhou Minghui, Maalim Ali Abdi, Han Yang, Guo Xiao, Chen Cao, Lei Ting, Shu Kai, Zhu Mingxin
Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Sci Rep. 2025 Jul 11;15(1):25153. doi: 10.1038/s41598-025-11035-5.
This study sought to evaluate the feasibility and effectiveness of the LEO or LEO baby within enterprise (EP) overlapping stents for treating ruptured vertebrobasilar artery dissecting aneurysms (VBDAs). A retrospective analysis was conducted on 20 patients with a total of 20 ruptured VBDAs, who received reconstructive treatment utilizing the LEO/LEO baby within enterprise overlapping stents combined with coil embolization, between December 2018 and June 2023. Patient characteristics, clinical outcomes, and radiological results were thoroughly reviewed. Functional data were evaluated using the modified Rankin scale (mRS). The outcomes for patients treated with the overlapping stent technique were compared to those of the single-stent treatment group which included 14 cases with LEO/LEO Baby stent and 12 cases with Enterprise stent. Among the 20 ruptured VBDAs identified, 13 were vertebral artery aneurysms (65.00%), and 7 were basilar artery aneurysms (35.00%). All cases were effectively treated during the acute phase of onset. Three patients (15.00%) experienced significant in-hospital adverse events, with one patient (5.00%) succumbing to rebleeding of the arterial aneurysm during the perioperative period. A follow-up period of at least six months was achieved for 19 patients. The rates of mortality or dependency (mRS scores of 3 to 6) were 15.00% at discharge and 10.00% at the final follow-up. Ischemic events occurred in two patients (10.00%); one during the perioperative period and one during follow-up. One patient (5.00%) required ventriculoperitoneal shunt placement. Immediate post-operation angiography revealed Raymond grade I, II, and III occlusions in 55.00%, 30.00%, and 15.00% of cases, respectively. At a mean follow-up of 14.84 ± 7.51 months, 17 patients (89.47%) had mRS scores of 0-2, indicating favorable outcomes, while two patients (10.53%) had scores between 3 and 6. The initial complete or near-complete obliteration rates of aneurysms were higher in the overlapping-stent group compared to the single-stent group (85.00% vs. 65.38%, P = 0.18). Follow-up angiography indicated superior rates of complete or near-complete aneurysm obliteration in the double-stent group (94.74% vs. 73.08%, P = 0.11). The overlapping stents technique, utilizing the LEO/LEO baby within EP stent configuration in conjunction with coiling, demonstrated both efficacy and safety in the treatment of ruptured VBDAs. Follow-up evaluations revealed a high rate of aneurysm occlusion, suggesting that this approach may offer a dependable intervention strategy for managing these complex cases.
本研究旨在评估LEO或LEO baby enterprise(EP)重叠支架治疗破裂性椎基底动脉夹层动脉瘤(VBDAs)的可行性和有效性。对20例共20个破裂性VBDAs患者进行回顾性分析,这些患者在2018年12月至2023年6月期间接受了使用LEO/LEO baby enterprise重叠支架联合弹簧圈栓塞的重建治疗。对患者特征、临床结果和影像学结果进行了全面回顾。使用改良Rankin量表(mRS)评估功能数据。将重叠支架技术治疗患者的结果与单支架治疗组进行比较,单支架治疗组包括14例使用LEO/LEO Baby支架和12例使用Enterprise支架的患者。在确定的20个破裂性VBDAs中,13个为椎动脉动脉瘤(65.00%),7个为基底动脉动脉瘤(35.00%)。所有病例在发病急性期均得到有效治疗。3例患者(15.00%)发生严重院内不良事件,1例患者(5.00%)在围手术期死于动脉瘤再出血。19例患者实现了至少6个月的随访。出院时死亡率或依赖率(mRS评分为3至6)为15.00%,最终随访时为10.00%。2例患者(10.00%)发生缺血性事件;1例在围手术期,1例在随访期间。1例患者(5.00%)需要进行脑室腹腔分流术。术后即刻血管造影显示,分别有55.00%、30.00%和