Pizzorni C, Sulli A, Smith V, Lladó A, Paolino S, Cutolo M, Ruaro B
Acta Reumatol Port. 2016 Jan-Mar;41(1):8-14.
Systemic sclerosis (SSc) is an autoimmune disorder of unknown aetiology characterized by early impairment of the microvascular system. Nailfold microangiopathy and decreased peripheral blood perfusion are typical clinical aspects of SSc. The best method to evaluate vascular injury is nailfold videocapillaroscopy, which detects peripheral capillary morphology, and classifies and scores the abnormalities into different patterns of microangiopathy. Microangiopathy appears to be the best evaluable predictor of the disease development and has been observed to precede the other symptoms by many years. Peripheral blood perfusion is also impaired in SSc, and there are different methods to assess it: laser Doppler and laser speckle techniques, thermography and other emerging techniques.
系统性硬化症（SSc）是一种病因不明的自身免疫性疾病，其特征为微血管系统早期受损。甲襞微血管病变和外周血灌注减少是SSc的典型临床症状。评估血管损伤的最佳方法是甲襞视频毛细血管显微镜检查，该检查可检测外周毛细血管形态，并将异常情况分类和评分，分为不同的微血管病变模式。微血管病变似乎是疾病发展的最佳可评估预测指标，并且已观察到它比其他症状早出现许多年。SSc患者的外周血灌注也会受损，评估外周血灌注有不同的方法：激光多普勒和激光散斑技术、热成像及其他新兴技术。
