Souza-Fonseca-Guimaraes Fernando
Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne VIC 3010, Australia and Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Discov Med. 2016 Mar;21(115):197-203.
Metastasis is the leading cause of cancer-related death, as effective therapies remain an unsolved challenge in the clinical management of disseminated disease. Despite studies over the last decade reinforcing the role of the immune system in controlling cancer progression, our knowledge of immune control of cancer metastasis is still quite poor. Natural killer (NK) cells are a critical component of innate immunity and are able to recognize and trigger cell death in tumors by detecting receptor expression abnormalities in transformed cells. Recent studies and clinical trials have highlighted that manipulation of NK cell activation can be used as an immunotherapy in cancer. In this review, I provide an overview of potential immunotherapies that modulate NK cell responses against tumor metastases.
转移是癌症相关死亡的主要原因，因为在播散性疾病的临床管理中，有效的治疗方法仍然是一个尚未解决的挑战。尽管过去十年的研究强化了免疫系统在控制癌症进展中的作用，但我们对癌症转移的免疫控制的了解仍然相当有限。自然杀伤（NK）细胞是先天免疫的关键组成部分，能够通过检测转化细胞中的受体表达异常来识别并触发肿瘤细胞死亡。最近的研究和临床试验表明，操纵NK细胞的激活可作为癌症的一种免疫疗法。在这篇综述中，我概述了调节NK细胞对肿瘤转移反应的潜在免疫疗法。
