Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Shuaifuyuan 1, Dongcheng District, 100730, Beijing, China.
J Exp Clin Cancer Res. 2020 Nov 4;39(1):231. doi: 10.1186/s13046-020-01727-3.
Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that are highly linked to various cellular functions and pathological process. Emerging evidence indicates that lncRNAs participate in crosstalk between tumor and stroma, and reprogramming of tumor immune microenvironment (TIME). TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. However, hitherto, a comprehensive review aiming at relationship between lncRNAs and TIME is missing. In this review, we focus on the functional roles and molecular mechanisms of lncRNAs within the TIME. Furthermore, we discussed the potential immunotherapeutic strategies based on lncRNAs and their limitations.
长非编码 RNA（lncRNAs）是一类内源性、非蛋白编码的 RNA，与多种细胞功能和病理过程密切相关。越来越多的证据表明，lncRNAs 参与肿瘤与基质之间的串扰以及肿瘤免疫微环境（TIME）的重编程。TIME 具有独特的髓系细胞和淋巴细胞群体，影响癌症的免疫逃逸、免疫治疗反应和患者的生存。然而，迄今为止，尚缺乏针对 lncRNAs 与 TIME 之间关系的全面综述。在这篇综述中，我们重点关注 lncRNAs 在 TIME 中的功能作用和分子机制。此外，我们还讨论了基于 lncRNAs 的潜在免疫治疗策略及其局限性。
