食管癌的潜在生物标志物。
Potential biomarkers for esophageal cancer.
作者信息
Tan Cheng, Qian Xia, Guan Zhifeng, Yang Baixia, Ge Yangyang, Wang Feng, Cai Jing
机构信息
Department of Radiation Oncology, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, Nantong, 226321 China.
出版信息
Springerplus. 2016 Apr 16;5:467. doi: 10.1186/s40064-016-2119-3. eCollection 2016.
Abstract
Esophageal cancer, which consist of esophageal adenocarcinoma and esophageal squamous cell carcinoma, is one of the most common malignant tumors in the world, especially in the south of Iran and China. To find and investigate the biomarkers in the initiation, development and progression of esophageal cancer will help us predict the prognosis of esophageal cancer patients and improve the curative effect and survival rate. Here, we reviewed the potential biomarkers of esophageal cancer in three aspects: Immunohistochemical markers, blood-based markers, miRNA markers and Gene expression profiling. All these biomarkers provided promising therapeutic targets for the diagnosis, treatment, and prognosis of esophageal cancer.
摘要
食管癌由食管腺癌和食管鳞状细胞癌组成，是世界上最常见的恶性肿瘤之一，尤其是在伊朗南部和中国。寻找并研究食管癌发生、发展和进展过程中的生物标志物，将有助于我们预测食管癌患者的预后，提高治疗效果和生存率。在此，我们从免疫组化标志物、血液标志物、miRNA标志物和基因表达谱三个方面综述了食管癌的潜在生物标志物。所有这些生物标志物为食管癌的诊断、治疗和预后提供了有前景的治疗靶点。
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