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[食管鳞状细胞癌术后病理特征对预后的影响]

[Impact of postoperative pathological features of esophageal squamous cell carcinoma on the prognosis].

作者信息

Xu Lei, Li Yin, Sun Haibo, Zheng Yan, Wang Zongfei, Chen Xiankai

机构信息

Department of Thoracic Surgery, The affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China.

出版信息

Zhonghua Wei Chang Wai Ke Za Zhi. 2017 Dec 25;20(12):1448-1451.

Abstract

Esophageal cancer is located in the 8th position of the incidence of malignant tumors and the 6th most common cause of cancer-related mortality in the world, while China has the highest incidence and mortality of esophageal cancer. Esophageal squamous cell carcinoma (ESCC), the predominant histologic type of esophageal cancer in China, accounts for about 90%. Despite recent improvement of surgical techniques and philosophy, however, the prognosis of ESCC patients treated with surgery is still poor, and 5-year survival remains unsatisfactorily low. So far, the pathogenesis of esophageal squamous cell carcinoma is still unclear, and effective prevention is also out of the question. To find the main factors affecting the prognosis of esophageal squamous cell carcinoma, and to improve the survival of patients, are the main directions of all scholars. Postoperative pathology of esophageal squamous cell carcinoma is considered to be one of the most important predictors of prognosis. Currently, the evaluation of postoperative esophageal prognosis mainly depends on TNM staging, but some criteria of its specific content and staging remains controversial. In this paper recent domestic and foreign related researches and clinical trials reports are collected, and the postoperative pathological features affecting esophageal squamous cell carcinoma prognosis were reviewed.

摘要

食管癌在全球恶性肿瘤发病率中位居第8位,是癌症相关死亡的第6大常见原因,而中国食管癌的发病率和死亡率最高。食管鳞状细胞癌(ESCC)是中国食管癌最主要的组织学类型,约占90%。尽管近年来手术技术和理念有所改进,但接受手术治疗的ESCC患者预后仍然较差,5年生存率仍低得不尽人意。迄今为止,食管鳞状细胞癌的发病机制仍不清楚,有效的预防也无从谈起。寻找影响食管鳞状细胞癌预后的主要因素并提高患者生存率,是所有学者的主要研究方向。食管鳞状细胞癌的术后病理被认为是最重要的预后预测指标之一。目前,食管癌术后预后评估主要依赖TNM分期,但其具体内容和分期的一些标准仍存在争议。本文收集了近期国内外相关研究及临床试验报告,对影响食管鳞状细胞癌预后的术后病理特征进行综述。

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