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儿童主动脉弓梗阻行主动脉旁路移植术的单中心经验

Single center experience of aortic bypass graft for aortic arch obstruction in children.

作者信息

Shinkawa Takeshi, Chipman Carl, Holloway Jessica, Tang Xinyu, Gossett Jeffrey M, Imamura Michiaki

机构信息

Division of Pediatric and Congenital Cardiothoracic Surgery, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, 1 Children's Way, Slot 677, Little Rock, AR, 72202, USA.

Biostatistics Program, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

出版信息

Heart Vessels. 2017 Jan;32(1):76-82. doi: 10.1007/s00380-016-0842-x. Epub 2016 Apr 27.

Abstract

The purpose of this study is to access the outcomes of aortic bypass graft placement in children. This is a retrospective review of all children having aortic bypass graft placement for aortic arch obstruction for the first time between 1982 and 2013 at a single institution. The actuarial survival and the freedom from aortic arch reoperation were calculated and compared between the groups. Seventy consecutive children underwent aortic bypass graft placements. The median age and body weight at the operation were 14 days and 3.6 kg. There were 7 early deaths, 6 late deaths, and 7 heart transplants during the median follow-up of 10.8 years (0.0-31.5 years). The actuarial transplant free survival was 64.7 % at 20 years and the freedom from aortic arch reoperation was 50.5 % at 10 years. Between the children younger than 1 year old and older than 1 year old, there were significant differences in actuarial transplant free survival (56.4 vs. 100 % at 15 years, p = 0.0042) and in the freedom from aortic arch reoperation (18.7 vs. 100 % at 10 years, p < 0.001). The children who received aortic bypass graft larger than 16 mm in size had no aortic arch reoperation at 15 years. The aortic bypass graft placement for aortic arch obstruction can be done with low mortality and morbidity for children who can receive bypass graft larger than 16 mm in size. However, it should be avoided for the neonates and infants except selected situations.

摘要

本研究的目的是评估儿童主动脉旁路移植术的疗效。这是一项对1982年至2013年间在单一机构首次因主动脉弓梗阻接受主动脉旁路移植术的所有儿童进行的回顾性研究。计算并比较了各组的精算生存率和主动脉弓再次手术的无复发生存率。连续70名儿童接受了主动脉旁路移植术。手术时的中位年龄和体重分别为14天和3.6千克。在中位随访10.8年(0.0 - 31.5年)期间,有7例早期死亡、6例晚期死亡和7例心脏移植。20年时的精算无移植生存率为64.7%,10年时主动脉弓再次手术的无复发生存率为50.5%。在1岁以下和1岁以上的儿童之间,精算无移植生存率(15年时分别为56.4%和100%,p = 0.0042)和主动脉弓再次手术的无复发生存率(10年时分别为18.7%和100%,p < 0.001)存在显著差异。接受尺寸大于16毫米主动脉旁路移植的儿童在15年时未进行主动脉弓再次手术。对于能够接受尺寸大于16毫米旁路移植的儿童,因主动脉弓梗阻进行主动脉旁路移植术的死亡率和发病率较低。然而,除特定情况外,应避免对新生儿和婴儿进行该手术。

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