Section of Cardiothoracic Surgery, James W. Riley Hospital for Children, Indianapolis, Indiana 46202-5123, USA.
Ann Thorac Surg. 2009 Dec;88(6):1923-30; discussion 1930-1. doi: 10.1016/j.athoracsur.2009.07.024.
Persistence or recurrence of stenosis is a complication of coarctation repair and is associated with major long-term morbidity. The rate of recurrence varies significantly, depending on the age of the patient, technique at initial repair, and the arch anatomy. We reviewed our experience with surgical repair of recurrent coarctation of the aorta and compared it with our institutional experience with balloon aortoplasty.
We retrospectively reviewed our experience with 1,012 patients undergoing initial repair of coarctation between 1960 and 2008. During that time, 103 patients (10%) required reintervention. Median age at reintervention was 6.5 years (range, 2 weeks to 44 years) and median weight was 12 kg (range, 1.9 to 94 kg). Fifty-nine patients with recoarctation had surgical repair, and 44 patients were treated with balloon aortoplasty with or without stent placement.
Ninety-five percent of patients have been followed up (median time, 14.2 years; range, 2 months to 42 years). There were 5 late deaths. Actuarial survival was 98% at 15 and 40 years in patients with surgical reintervention, and it was 91% (p = 0.001) at 15 years in patients with balloon aortoplasty reintervention. A second redo coarctation of the aorta reintervention was performed in 12 patients: 8 patients after percutaneous intervention (nonsurgical) and 4 patients after surgical recoarctation repair. The median interval between first and second reintervention was 3.5 years (range, 1 month to 14 years). One patient who had two dilations underwent a third and fourth reintervention: patch enlargement and pseudoaneurysm resection. Freedom from reintervention in the surgical group was 96% at 15 years and 94% at 40 years, which was compared with actuarial freedom from reintervention for patients with percutaneous intervention (balloon/stent) at 15 years (82%; p < 0.001).
Our study demonstrates that surgical repair of recurrent coarctation of the aorta can be performed safely and with excellent results. The recurrence after surgical reintervention is low, and most patients to date have not required further intervention. Balloon aortoplasty as an alternative method of managing recoarctation is efficient and less invasive than surgery; however, well-described complications may occur. Recurrence rates with angioplasty are significantly higher than with surgery.
狭窄的持续性或复发是主动脉缩窄修复的并发症,与主要的长期发病率有关。复发率差异很大,取决于患者的年龄、初次修复时的技术以及弓部解剖结构。我们回顾了我们在复发性主动脉缩窄手术修复方面的经验,并将其与我们机构在球囊主动脉成形术中的经验进行了比较。
我们回顾性分析了 1960 年至 2008 年间接受初次主动脉缩窄修复的 1012 例患者的经验。在此期间,103 例(10%)需要再次干预。再次干预时的中位年龄为 6.5 岁(范围:2 周至 44 岁),中位体重为 12 公斤(范围:1.9 至 94 公斤)。59 例再狭窄患者接受了手术修复,44 例患者接受了球囊主动脉成形术,伴或不伴支架置入。
95%的患者得到了随访(中位时间为 14.2 年,范围:2 个月至 42 年)。有 5 例晚期死亡。手术再干预患者的 15 年和 40 年 actuarial 生存率分别为 98%,球囊主动脉成形术再干预患者的 15 年生存率为 91%(p = 0.001)。12 例患者行第二次再狭窄修复:8 例经皮介入(非手术),4 例经手术再狭窄修复。首次和第二次再干预之间的中位间隔为 3.5 年(范围:1 个月至 14 年)。1 例接受两次扩张的患者行第三次和第四次再干预:补片扩大和假性动脉瘤切除。手术组的无再干预生存率为 15 年 96%,40 年 94%,与经皮介入(球囊/支架)患者 15 年的无再干预生存率(82%;p < 0.001)相比具有显著优势。
我们的研究表明,主动脉缩窄复发性狭窄的手术修复是安全有效的,且效果极好。手术再干预后的复发率较低,到目前为止,大多数患者不需要进一步干预。球囊主动脉成形术作为一种替代治疗再狭窄的方法,与手术相比,具有效率高、创伤小的优点;但是,可能会发生明确描述的并发症。血管成形术的复发率明显高于手术。