Hamed Ahmed R, Hegazy Mohamed-Elamir F, Higgins Maureen, Mohamed Tarik A, Abdel-Azim Nahla S, Pare Paul W, Dinkova-Kostova Albena T
Phytochemistry Department, National Research Centre, 33 El Bohouth st., Dokki, P.O. Box 12622, Giza, Egypt.
Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine, University of Dundee, Dundee, DD1 9SY, Scotland, UK.
J Nat Med. 2016 Jul;70(3):683-8. doi: 10.1007/s11418-016-0994-0. Epub 2016 Apr 27.
Medicinal plants from the Egyptian Sinai Peninsula are widely used in traditional Bedouin medicine to treat a range of conditions including cancer, and as such are a promising resource for novel anti-cancer compounds. To achieve scientific justification of traditional use and/or to recommend the use of those plants as medicinal herbs for cancer chemoprevention, a group of 11 Sinai plants of different species that belong to 3 families (Asteraceae, Lamiaceae, and Euphorbiaceae) were biologically screened for cancer preventive activity using the chemoprevention marker enzyme
NAD(P)H: quinone oxidoreductase 1 (NQO1). Among the fractions assayed, a solvent extract from Pulicaria incisa had potent NQO1 inducing activity. Further analysis of the mechanism of induction revealed the concentration-dependent stabilization of the transcription factor NF-E2 p45-related factor 2 (Nrf2) and a coordinate upregulation of the Nrf2-dependent enzymes NQO1, heme oxygenase 1 and glutathione S-transferase-Pi. These results establish P. incisa as a promising target for future phytochemical characterization for cancer preventive components.
来自埃及西奈半岛的药用植物在传统贝都因医学中被广泛用于治疗包括癌症在内的一系列病症，因此是新型抗癌化合物的一个有前景的资源。为了实现传统用途的科学论证和/或推荐将这些植物用作癌症化学预防的草药，对属于3个科（菊科、唇形科和大戟科）的11种不同物种的西奈植物进行了生物学筛选，以使用化学预防标记酶NAD(P)H：醌氧化还原酶1（NQO1）检测其癌症预防活性。在所检测的组分中，来自切刻普里卡利亚（Pulicaria incisa）的一种溶剂提取物具有强大的NQO1诱导活性。对诱导机制的进一步分析揭示了转录因子NF-E2 p45相关因子2（Nrf2）的浓度依赖性稳定以及Nrf2依赖性酶NQO1、血红素加氧酶1和谷胱甘肽S-转移酶-Pi的协同上调。这些结果确立了切刻普里卡利亚作为未来对癌症预防成分进行植物化学表征的一个有前景的目标。
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