Johnson Sarah-Anne, O'Beirne Greg A, Lin Emily, Gourley John, Hornibrook Jeremy
a Department of Communication Disorders , University of Canterbury , Christchurch , New Zealand ;
b Department of Otolaryngology-Head and Neck Surgery and Audiology , Christchurch Hospital , Christchurch , New Zealand.
Acta Otolaryngol. 2016 Oct;136(10):1029-34. doi: 10.1080/00016489.2016.1175663. Epub 2016 Apr 28.
To measure ocular vestibular-evoked myogenic potentials (oVEMPs) and cervical vestibular-evoked myogenic potentials (cVEMPS) in Menière's disease patients with confirmed cochlear hydrops and in the normal ears of volunteers.
oVEMPs and cVEMPs were measured in 18 patients with a symptomatic diagnosis of Menière's disease and tone burst electrocochleographic confirmation of hydrops, and in the ears of 22 volunteers.
Threshold measures: For cVEMP: no significant differences between Menière's ears and controls; for oVEMP: significantly elevated thresholds in affected ears of Menière's ears compared with their unaffected ears, but not with controls. Latency measures: cVEMP N1 peaks were significantly prolonged compared with the left and right ears of controls, but not with the non-affected ear. Amplitude measures: cVEMP P1N1 and N1P2 measures were significantly reduced compared with the right ear of controls, but not with the non-affected ear; For oVEMP, N2P2 amplitudes were significantly reduced compared with both ears of controls but not with the non-affected ear.
Abnormalities of oVEMPs and cVEMPs were found in 18 Menière's disease patients who had an independent confirmation of cochlear hydrops. The overlap of the results from Menière's patients compared with normal controls limits the use of VEMP abnormalities as a sole reliable diagnostic test for Menière's disease.
测量确诊为蜗管积水的梅尼埃病患者以及志愿者正常耳的眼前庭诱发肌源性电位（oVEMP）和颈前庭诱发肌源性电位（cVEMP）。
对18例有梅尼埃病症状诊断且经短纯音电耳蜗图证实有积水的患者以及22名志愿者的耳朵进行oVEMP和cVEMP测量。
阈值测量：对于cVEMP：梅尼埃病耳与对照组之间无显著差异；对于oVEMP：梅尼埃病患耳的阈值与其未患耳相比显著升高，但与对照组相比无差异。潜伏期测量：与对照组的左耳和右耳相比，cVEMP的N1峰显著延长，但与未患耳相比无差异。幅度测量：与对照组的右耳相比，cVEMP的P1N1和N1P2测量值显著降低，但与未患耳相比无差异；对于oVEMP，与对照组的双耳相比，N2P2幅度显著降低，但与未患耳相比无差异。
在18例经独立证实有蜗管积水的梅尼埃病患者中发现oVEMP和cVEMP异常。与正常对照组相比，梅尼埃病患者的结果存在重叠，这限制了将VEMP异常作为梅尼埃病唯一可靠诊断测试的应用。
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