Jerin Claudia, Berman Albert, Krause Eike, Ertl-Wagner Birgit, Gürkov Robert
German Center for Vertigo and Balance Disorders, Grosshadern Medical Center, University of Munich, Marchioninistr. 15, 81377 Munich, Germany.
German Center for Vertigo and Balance Disorders, Grosshadern Medical Center, University of Munich, Marchioninistr. 15, 81377 Munich, Germany.
Hear Res. 2014 Apr;310:54-9. doi: 10.1016/j.heares.2014.02.001. Epub 2014 Feb 14.
Ocular vestibular evoked myogenic potentials (oVEMP) represent extraocular muscle activity in response to vestibular stimulation. To specify the value of oVEMP in the diagnostics of Menière's disease, the amplitude ratio between 500 and 1000 Hz stimuli was investigated. Thirty-nine patients with certain Menière's disease, i.e. definite Menière's disease with visualization of endolymphatic hydrops by magnetic resonance imaging and 19 age-matched healthy controls were enrolled in this study. oVEMP were recorded using 500 and 1000 Hz air-conducted tone bursts. For Menière's ears, the 500/1000 Hz amplitude ratio (mean ratio = 1.20) was significantly smaller when compared to unaffected ears of Menière's patients (mean ratio = 1.80; p = 0.008) or healthy controls (mean ratio = 1.81; p = 0.011). The amplitude ratio was neither correlated with the degree of endolymphatic hydrops nor with the duration of disease. While an older age was associated with a diminished amplitude ratio in healthy controls, there was no correlation between the amplitude ratio and age in Menière's ears. Hence, the calculation of the oVEMP 500/1000 Hz amplitude ratio may be a valuable diagnostic tool for Menière's disease.
眼性前庭诱发肌源性电位（oVEMP）代表了眼外肌对前庭刺激的反应活动。为明确oVEMP在梅尼埃病诊断中的价值，研究了500和1000赫兹刺激之间的振幅比。本研究纳入了39例确诊为梅尼埃病的患者，即通过磁共振成像显示有内淋巴积水的明确梅尼埃病患者，以及19名年龄匹配的健康对照者。使用500和1000赫兹的气导短音记录oVEMP。对于患梅尼埃病的耳朵，500/1000赫兹的振幅比（平均比值=1.20）与梅尼埃病患者未受影响的耳朵（平均比值=1.80；p=0.008）或健康对照者（平均比值=1.81；p=0.011）相比显著更小。该振幅比既与内淋巴积水程度无关，也与病程无关。虽然在健康对照者中年龄较大与振幅比降低有关，但在患梅尼埃病的耳朵中，振幅比与年龄之间没有相关性。因此，计算oVEMP 500/1000赫兹的振幅比可能是梅尼埃病的一种有价值的诊断工具。
