Zhong Zhuliang, Zhao Gaoyuan, Xu Dengyu, Dong Baobiao, Song Dengpeng, Xie Xingang, She Xuegong
State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, 222 South Tianshui Road, Lanzhou, 730000, P. R. China.
Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300071, P. R. China.
Chem Asian J. 2016 May 20;11(10):1542-7. doi: 10.1002/asia.201600398. Epub 2016 May 3.
The first bioinspired total syntheses of (-) kravanhins A and C were accomplished from a labdane diterpenoid derivative. The key reactions involve a photooxidation and a one-pot sequential aldol cyclization and lactonization, which provide a new plausible biosynthetic pathway for the kravanhins and other symbiotic members.
首次通过一种半日花烷二萜衍生物完成了（-）kravanhins A和C的仿生全合成。关键反应包括光氧化反应以及一锅法顺序进行的羟醛缩合环化反应和内酯化反应，这为kravanhins及其他共生成员提供了一条新的合理生物合成途径。
