Jansson Leif, Barbu Andreea, Bodin Birgitta, Drott Carl Johan, Espes Daniel, Gao Xiang, Grapensparr Liza, Källskog Örjan, Lau Joey, Liljebäck Hanna, Palm Fredrik, Quach My, Sandberg Monica, Strömberg Victoria, Ullsten Sara, Carlsson Per-Ola
a Department of Medical Cell Biology , Uppsala University , Uppsala , Sweden ;
b Department of Medical Sciences , Uppsala University , Uppsala , Sweden.
Ups J Med Sci. 2016 May;121(2):81-95. doi: 10.3109/03009734.2016.1164769. Epub 2016 Apr 28.
Pancreatic islets are richly vascularized, and islet blood vessels are uniquely adapted to maintain and support the internal milieu of the islets favoring normal endocrine function. Islet blood flow is normally very high compared with that to the exocrine pancreas and is autonomously regulated through complex interactions between the nervous system, metabolites from insulin secreting β-cells, endothelium-derived mediators, and hormones. The islet blood flow is normally coupled to the needs for insulin release and is usually disturbed during glucose intolerance and overt diabetes. The present review provides a brief background on islet vascular function and especially focuses on available techniques to measure islet blood perfusion. The gold standard for islet blood flow measurements in experimental animals is the microsphere technique, and its advantages and disadvantages will be discussed. In humans there are still no methods to measure islet blood flow selectively, but new developments in radiological techniques hold great hopes for the future.
胰岛血管丰富，胰岛血管具有独特的适应性，以维持和支持胰岛的内部环境，有利于正常的内分泌功能。与外分泌胰腺相比，胰岛血流量通常非常高，并且通过神经系统、胰岛素分泌β细胞产生的代谢产物、内皮衍生介质和激素之间的复杂相互作用进行自主调节。胰岛血流量通常与胰岛素释放的需求相匹配，在葡萄糖耐量异常和显性糖尿病期间通常会受到干扰。本综述简要介绍了胰岛血管功能的背景知识，尤其关注测量胰岛血流灌注的现有技术。实验动物中测量胰岛血流的金标准是微球技术，将讨论其优缺点。在人类中，仍然没有选择性测量胰岛血流的方法，但放射技术的新进展为未来带来了巨大希望。
