Kavand Sima, Lehman Julia S, Gibson Lawrence E
From the Department of Medicine, Presence Saint Francis Hospital, University of Illinois, Evanston.
Departments of Dermatology, Pathology and Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, MN.
Am J Clin Pathol. 2016 Mar;145(3):401-6. doi: 10.1093/ajcp/aqw004. Epub 2016 Mar 2.
To elucidate whether granuloma faciale (GF) and erythema elevatum diutinum (EED), two inflammatory skin dermatoses, meet the consensus histopathologic diagnostic criteria for immunoglobulin G4-related disease (IgG4-RD).
With institutional review board approval, we assessed the clinical, microscopic, and immunophenotypic features of skin specimens of patients with GF and EED. We compared these findings with previously published consensus diagnostic criteria for IgG4-RD.
Thirty-two patients (GF, n = 25; EED, n = 7) met study inclusion criteria. Histopathologic findings of small-vessel vasculitis, dermal fibrosis, and plasma cell infiltrates were uniformly present, and eosinophilic inflammation was frequent. No specimen met diagnostic criteria for IgG4-RD.
Our results indicate that despite some histopathologic similarities between GF/EED and IgG4-RD, the cases did not meet the consensus immunohistochemical diagnostic criteria for IgG4-RD.
阐明两种炎症性皮肤病，即面部肉芽肿（GF）和持久性隆起性红斑（EED），是否符合免疫球蛋白G4相关疾病（IgG4-RD）的共识组织病理学诊断标准。
经机构审查委员会批准，我们评估了GF和EED患者皮肤标本的临床、显微镜和免疫表型特征。我们将这些发现与先前发表的IgG4-RD共识诊断标准进行了比较。
32例患者（GF，n = 25；EED，n = 7）符合研究纳入标准。均出现小血管炎、真皮纤维化和浆细胞浸润的组织病理学表现，且常见嗜酸性炎症。没有标本符合IgG4-RD的诊断标准。
我们的结果表明，尽管GF/EED与IgG4-RD之间存在一些组织病理学相似性，但这些病例不符合IgG4-RD的共识免疫组织化学诊断标准。
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