Marcoval Joaquim, Moreno Abelardo, Peyr Jordi
Department of Dermatology, Hospital de Bellvitge, University of Barcelona, Spain.
J Am Acad Dermatol. 2004 Aug;51(2):269-73. doi: 10.1016/j.jaad.2003.11.071.
Granuloma faciale is an uncommon disease of unknown etiology that is often misdiagnosed clinically and by general pathologists.
To describe the clinicopathological features of a series of patients with granuloma faciale.
Eleven patients diagnosed with granuloma faciale between 1990 and 2002 were included in the study.
Granuloma faciale was diagnosed in 11 patients (9 male and 2 female, mean age 53.45 years). All of them presented facial cutaneous lesions and two of them also developed extrafacial lesions. Histologically, in 8 cases the infiltrate was limited to the upper half of the dermis. Two specimens showed fibrinoid necrosis. Concentric fibrosis around small blood vessels was demonstrated in 5 patients.
The presence of abundant fibrosis in 5 of our patients similar to that observed in erythema elevatum diutinum suggests that granuloma faciale and erythema elevatum diutinum may be produced by similar or the same pathogenic mechanism.
面部肉芽肿是一种病因不明的罕见疾病，临床和普通病理学家常常误诊。
描述一系列面部肉芽肿患者的临床病理特征。
本研究纳入了1990年至2002年间诊断为面部肉芽肿的11例患者。
11例患者（9例男性，2例女性，平均年龄53.45岁）被诊断为面部肉芽肿。所有患者均有面部皮肤损害，其中2例还出现了面部以外的损害。组织学上，8例患者的浸润局限于真皮上半层。2份标本显示纤维蛋白样坏死。5例患者可见小血管周围同心性纤维化。
我们的5例患者中存在丰富的纤维化，类似于持久性隆起性红斑中观察到的情况，这表明面部肉芽肿和持久性隆起性红斑可能由相似或相同的致病机制引起。
