Kato Hiroki, Ozeki Michio, Fukao Toshiyuki, Matsuo Masayuki
Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Department of Pediatrics, Gifu University School of Medicine, Gifu, Japan.
Neuroradiology. 2016 Aug;58(8):801-6. doi: 10.1007/s00234-016-1691-0. Epub 2016 Apr 28.
The present study aimed to assess the craniofacial CT imaging features for differentiating between Gorham-Stout disease (GSD) and generalized lymphatic anomaly (GLA).
Seven patients with GSD and four patients with GLA were included in this study. All patients underwent CT examinations that encompassed the craniofacial bones. The presence, distribution, and type of craniofacial osteolysis were assessed. The clinical symptoms that were associated with craniofacial osteolysis were also reviewed.
Craniofacial osteolysis including cranial osteolysis was seen in four of seven (57 %) patients with GSD and in three of four (75 %) patients with GLA. Facial osteolysis was seen in two (29 %) patients with GSD, but this was not observed in patients with GLA. Among patients with craniofacial osteolysis, those with GSD showed diffuse involvement, whereas those with GLA showed multifocal involvement. The craniofacial osteolysis of GSD could be classified into three patterns: medullary involvement, thinning bone, and disappearing bone. The clinical symptoms of craniofacial osteolysis were observed in all patients with GSD but were not present in patients with GLA.
Craniofacial involvement was observed in both groups. The craniofacial osteolysis of GSD showed diffuse involvement with clinical symptoms, whereas that of GLA showed multifocal involvement without clinical symptoms.
本研究旨在评估颅面部CT成像特征，以鉴别戈勒姆-斯托特病（GSD）和泛发性淋巴管畸形（GLA）。
本研究纳入了7例GSD患者和4例GLA患者。所有患者均接受了包括颅面部骨骼的CT检查。评估颅面部骨质溶解的存在、分布和类型。还回顾了与颅面部骨质溶解相关的临床症状。
7例GSD患者中有4例（57%）出现包括颅骨骨质溶解在内的颅面部骨质溶解，4例GLA患者中有3例（75%）出现。2例（29%）GSD患者出现面部骨质溶解，但GLA患者未观察到。在颅面部骨质溶解患者中，GSD患者表现为弥漫性受累，而GLA患者表现为多灶性受累。GSD的颅面部骨质溶解可分为三种类型：骨髓受累、骨质变薄和骨质消失。所有GSD患者均观察到颅面部骨质溶解的临床症状，而GLA患者未出现。
两组均观察到颅面部受累。GSD的颅面部骨质溶解表现为伴有临床症状的弥漫性受累，而GLA的颅面部骨质溶解表现为无临床症状的多灶性受累。
