Habert R, Veniard B, Brignaschi P, Gangnerau M N, Picon R
Laboratoire de Physiologie du Développement et U.A. C.N.R.S. no. 307, Universite Paris, France.
Arch Androl. 1989;22(1):41-8. doi: 10.3109/01485018908986749.
In the rat during the last 4 days of fetal life, the production of testosterone by the testis does not increase, whereas the plasma level of biological LH-like activity rises sharply. The present study was designed to test whether this phenomenon is attributed to the development of defects in the activity of the enzyme 17 alpha-hydroxylase and C17,20-lyase (called late steroidogenic lesions) during the end of fetal life. As this occurrence would lead to an age-related decrease in the ratio testosterone/progesterone, the testicular productions of these two steroids were evaluated on 18.5, 20.5, and 21.5 days postconception. Three different measurements were performed: (a) the in vivo testicular contents; (b) the in vitro secretions during a 120-min incubation in the presence or in the absence of 100 ng/ml ovine LH; (c) the testicular contents after these incubations. These measurements never revealed a decrease in the ratio testosterone/progesterone as a function of fetal age. It would appear that late steroidogenic lesions do not develop during the end of fetal life in the rat.
在胎鼠生命的最后4天，睾丸的睾酮生成量并未增加，而血浆中生物活性促黄体生成素（LH）样活性水平却急剧上升。本研究旨在测试这种现象是否归因于胎鼠生命末期17α-羟化酶和C17,20-裂解酶活性缺陷的发展（称为晚期类固醇生成损伤）。由于这种情况会导致睾酮/孕酮比值随年龄增长而降低，因此在受孕后18.5、20.5和21.5天评估了这两种类固醇的睾丸生成量。进行了三种不同的测量：（a）体内睾丸含量；（b）在存在或不存在100 ng/ml绵羊LH的情况下孵育120分钟期间的体外分泌量；（c）这些孵育后的睾丸含量。这些测量从未显示睾酮/孕酮比值随胎龄增加而降低。看来在胎鼠生命末期不会发生晚期类固醇生成损伤。
