Mishra G, Behera H N
Postgraduate Department of Zoology, Berhampur University, Orissa, India.
Arch Gerontol Geriatr. 1989 Jan;8(1):1-12. doi: 10.1016/0167-4943(89)90064-2.
In the present study the effect of two chemicals such as methylene blue and CoCl2 on the accelerated ageing of collagen in alloxan-diabetic lizards has been tested. Both methylene blue and CoCl2 have been found to accelerate the ageing of collagen in normal lizards. While methylene blue enhanced the effects of alloxan in alloxanized lizards, CoCl2 tended to reverse it. It appears that methylene blue acts as a potentiator of alloxan; CoCl2, on the contrary, showed clear anti-ageing effects.
在本研究中，测试了亚甲蓝和氯化钴这两种化学物质对四氧嘧啶糖尿病蜥蜴胶原蛋白加速老化的影响。已发现亚甲蓝和氯化钴均可加速正常蜥蜴胶原蛋白的老化。亚甲蓝增强了四氧嘧啶对注射四氧嘧啶蜥蜴的作用，而氯化钴则倾向于逆转这种作用。看来亚甲蓝作为四氧嘧啶的增效剂；相反，氯化钴显示出明显的抗衰老作用。
