Morehead R T, Olsen T A, Drake E H, Muckerheide M
Wausau Hospital Center, WI 54401.
Aviat Space Environ Med. 1989 Mar;60(3):235-40.
This experiment tested a self-contained blood grouping device under microgravity as well as the possibility that gravity could affect the blood grouping reaction. The experiment tested Rh, ABO, and Coombs-sensitized human erythrocytes against their appropriate antisera and diluents. A self-contained device was built which accomplished the agglutination and collected the agglutinates on filter paper. This was flown on the Columbia Space Shuttle on Jan. 12, 1986. The device produced blood agglutinates to several blood groups and the agglutinates were held on filter paper until returned to us by NASA as soon as practical after landing. Both the Rh test and Rh control systems failed because of crystallization within the tubing. The remaining three systems functioned as expected. After comparing these results to similar experiments conducted under full gravity, we conclude that ABO and Coombs-sensitized blood grouping tests do occur under micro-gravity, although the agglutinates formed may be smaller. The use of a closed system for clinical laboratory examination in space is demonstrated.
本实验测试了一种在微重力环境下的独立血型鉴定装置，以及重力是否会影响血型鉴定反应的可能性。该实验针对Rh、ABO和库姆斯致敏的人类红细胞与其相应的抗血清和稀释剂进行了测试。构建了一个独立装置，该装置可完成凝集反应并将凝集物收集在滤纸上。此装置于1986年1月12日搭载哥伦比亚号航天飞机飞行。该装置对几种血型产生了血液凝集物，并且凝集物被保留在滤纸上，直到着陆后美国国家航空航天局（NASA）尽快将其归还我们。由于管道内结晶，Rh测试和Rh控制系统均失败。其余三个系统按预期运行。将这些结果与在全重力条件下进行的类似实验进行比较后，我们得出结论，ABO和库姆斯致敏血型鉴定测试在微重力环境下确实会发生，尽管形成的凝集物可能较小。证明了在太空中使用封闭系统进行临床实验室检查的可行性。
