Ellulu Mohammed S, Khaza'ai Huzwah, Rahmat Asmah, Patimah Ismail, Abed Yehia
Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Malaysia.
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Malaysia.
Int J Cardiol. 2016 Jul 15;215:318-24. doi: 10.1016/j.ijcard.2016.04.089. Epub 2016 Apr 14.
To find out the differences on biomedical data between obese and non-obese participants, and to identify risk factors associated with systemic inflammation in healthy Palestinian adults.
A cross-sectional study involved 105 apparently healthy adults. Interview questionnaire was used to collect personal information. Participants were excluded if they suffered from acute or chronic inflammatory diseases, or continued using medicines, which might affect the biomedical results.
In association with increased Body Mass Index (BMI), the obese group displayed significant higher markers including: interleukin 6 (IL-6), high sensitivity C reactive protein (hs-CRP), total cholesterol (TC), systolic blood pressure (SBP), and diastolic blood pressure (DBP). Obese group in association with increased waist circumference (WC) was higher significantly in inflammatory markers (IL-6, hs-CRP), lipid profile (TC) and triglyceride (TG), and blood pressure (SBP, DBP). A tertile of a feature of systemic inflammation (hs-CRP) was created, by Ordinal Logistic Regression, after adjusting for the age, gender, smoking habits, physical activity pattern, father and mother's health history; risk factors were the increased BMI [OR: 1.24] (95% CI: 1.005-1.548, P=0.050), IL-6 [OR: 3.35] (95% CI: 1.341-8.398, P=0.010), DBP [OR: 1.19] (95% CI: 1.034-1.367, P=0.015), and reduced Adiponectin [OR: 0.59] (95% CI: 0.435-0.820, P=0.001). Finally, BMI correlated with IL-6 and hs-CRP (r=0.326, P=0.005; r=0.347, P<0.001; respectively), and hs-CRP correlated with IL-6 (r=0.303, P=0.010), and inversely with Adiponectin (r=-0.342, P=0.001).
The increased level of IL-6 and reduced Adiponectin, which strongly associated with obesity, indicated that having high BMI is a useful marker in association with IL-6 and further developed systemic inflammation.
为了找出肥胖与非肥胖参与者在生物医学数据上的差异，并确定健康的巴勒斯坦成年人中与全身炎症相关的风险因素。
一项横断面研究涉及105名表面健康的成年人。采用访谈问卷收集个人信息。如果参与者患有急性或慢性炎症性疾病，或持续使用可能影响生物医学结果的药物，则将其排除。
与体重指数（BMI）升高相关，肥胖组的标志物显著更高，包括：白细胞介素6（IL-6）、高敏C反应蛋白（hs-CRP）、总胆固醇（TC）、收缩压（SBP）和舒张压（DBP）。与腰围（WC）增加相关的肥胖组在炎症标志物（IL-6、hs-CRP）、血脂谱（TC）和甘油三酯（TG）以及血压（SBP、DBP）方面显著更高。通过有序逻辑回归，在调整年龄、性别、吸烟习惯、身体活动模式、父母健康史后，建立了全身炎症特征（hs-CRP）的三分位数；风险因素包括BMI升高[比值比（OR）：1.24]（95%置信区间：1.005 - 1.548，P = 0.050）、IL-6[OR：3.35]（95%置信区间：1.341 - 8.398，P = 0.010）、DBP[OR：1.19]（95%置信区间：1.034 - 1.367，P = 0.015）以及脂联素降低[OR：0.59]（95%置信区间：0.435 - 0.820，P = 0.001）。最后，BMI与IL-6和hs-CRP相关（r = 0.326，P = 0.005；r = 0.347，P < 0.001；分别），hs-CRP与IL-6相关（r = 0.303，P = 0.010），与脂联素呈负相关（r = -0.342，P = 0.001）。
IL-6水平升高和脂联素降低与肥胖密切相关，表明高BMI是与IL-6及进一步发展的全身炎症相关的有用标志物。
