Department of Geriatrics, Division of Biochemistry and Biogerontology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85626, Bydgoszcz, Poland.
Department of Clinical Neuropsychology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85094, Bydgoszcz, Poland.
Obes Surg. 2024 Oct;34(10):3824-3832. doi: 10.1007/s11695-024-07468-y. Epub 2024 Aug 24.
Bariatric surgery poses an ever-increasing importance in the effective and long-lasting treatment of obesity, a condition strongly associated with inflammation and increased risk of other diseases and health problems. In obesity-related inflammation, maintaining a balance between pro-inflammatory and anti-inflammatory cytokines is crucial. In this study, we examined early effects of laparoscopic sleeve gastrectomy (LSG) on inflammatory and anti-inflammatory cytokines in obese patients, and assessed their effect on postoperative weight loss.
This prospective cohort study was conducted from September 2022 till June 2023. Fifty obese adults were enrolled for LSG. All patients underwent assessments of body measurements, as well as levels of interleukin-6 (IL-6), interleukin-10 (IL-10), and TNF-alpha at baseline and 3 months postsurgery. We developed a decision tree model to predict the success of weight loss.
At 3 months postsurgery, patients lost 18.9 ± 6.9 kg of excess body weight. A significant decrease was observed for IL-10 (p < 0.0001), simultaneously with a significant increase in IL-6 (p < 0.0001). We found that high IL-6 (> 1.169 pg/mL) levels could contribute to an effective weight loss among patients with a baseline BMI less than 47.46 kg/m.
Study revealed that 3 months after bariatric surgery, inflammation persists, and its markers significantly influence postoperative weight loss, as indicated by BMI range. Distinct behaviors of IL-10 and IL-6 in relation to obesity underline the necessity of considering individual cytokine profiles when evaluating bariatric surgery outcomes.
减重手术在肥胖症的有效和长期治疗中具有越来越重要的作用，肥胖症与炎症和其他疾病及健康问题的风险增加密切相关。在肥胖相关炎症中，维持促炎细胞因子和抗炎细胞因子之间的平衡至关重要。在这项研究中，我们研究了腹腔镜袖状胃切除术（LSG）对肥胖患者炎症和抗炎细胞因子的早期影响，并评估了它们对术后体重减轻的影响。
本前瞻性队列研究于 2022 年 9 月至 2023 年 6 月进行。50 名肥胖成年人被纳入 LSG。所有患者在基线和术后 3 个月进行身体测量评估以及白细胞介素 6（IL-6）、白细胞介素 10（IL-10）和肿瘤坏死因子-α（TNF-α）水平的评估。我们开发了一个决策树模型来预测减肥的成功。
术后 3 个月，患者减轻了 18.9±6.9kg 的多余体重。IL-10 显著下降（p<0.0001），同时 IL-6 显著增加（p<0.0001）。我们发现，基线 BMI 小于 47.46kg/m 的患者中，IL-6 水平较高（>1.169pg/mL）有助于有效减肥。
研究表明，减重手术后 3 个月，炎症仍然存在，其标志物显著影响术后体重减轻，这表明 BMI 范围。IL-10 和 IL-6 与肥胖的关系表明，在评估减重手术结果时，有必要考虑个体细胞因子谱。
