Kudesia Rashmi, Kuokkanen Satu
a Montefiore Medical Center/Albert Einstein College of Medicine , Bronx , NY , USA.
c RMA NY, Icahn School of Medicine , NY , USA.
Gynecol Endocrinol. 2016 Sep;32(9):701-703. doi: 10.1080/09513590.2016.1177813. Epub 2016 Apr 29.
Receptive endometrium is essential for successful implantation and ongoing pregnancy. Significant health issues and associated therapies, especially oncologic therapies, have potential to negatively impact future fertility in young women. Irradiation and chemotherapeutic alkylating agents are known to cause ovarian failure in most females; however, less well is characterized the impact of irradiation on uterine development and integrity. With an increasing number of cancer survivors, women are seeking infertility treatment after such therapies. Here, we present a young woman who developed ovarian failure after the treatment of acute myeloid leukemia with bone marrow transplant and preceding irradiation and chemotherapy and who was diagnosed with thin endometrial lining while seeking infertility therapy.
接受性子宫内膜对于成功着床和维持妊娠至关重要。重大健康问题及相关治疗，尤其是肿瘤治疗，有可能对年轻女性未来的生育能力产生负面影响。已知放疗和化疗烷化剂会导致大多数女性卵巢功能衰竭；然而，放疗对子宫发育和完整性的影响却鲜为人知。随着癌症幸存者数量的增加，女性在接受此类治疗后寻求不孕治疗。在此，我们介绍一位年轻女性，她在接受急性髓系白血病骨髓移植及术前放疗和化疗后出现卵巢功能衰竭，并在寻求不孕治疗时被诊断为子宫内膜薄。
