McKenna Olivia E, Asam Claudia, Araujo Galber R, Roulias Anargyros, Goulart Luiz R, Ferreira Fatima
Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
Laboratory of Nanobiotechnology, Institute of Genetics and Biochemistry, Federal University of Uberlandia, Uberlandia, Brazil.
Pediatr Allergy Immunol. 2016 Sep;27(6):560-8. doi: 10.1111/pai.12589.
Panallergens comprise various protein families of plant as well as animal origin and are responsible for wide IgE cross-reactivity between related and unrelated allergenic sources. Such cross-reactivities include reactions between various pollen sources, pollen and plant-derived foods as well as invertebrate-derived inhalants and foodstuff. Here, we provide an overview on the most clinically relevant panallergens from plants (profilins, polcalcins, non-specific lipid transfer proteins, pathogenesis-related protein family 10 members) and on the prominent animal-derived panallergen family, tropomyosins. In addition, we explore the role of panallergens in the sensitization process and progress of the allergic disease. Emphasis is given on epidemiological aspects of panallergen sensitization and clinical manifestations. Finally, the issues related to diagnosis and therapy of patients sensitized to panallergens are outlined, and the use of panallergens as predictors for cross-reactive allergy and as biomarkers for disease severity is discussed.
泛变应原包括各种植物和动物来源的蛋白质家族，它们导致相关和不相关变应原来源之间广泛的IgE交叉反应。这种交叉反应包括各种花粉来源之间、花粉与植物源性食物之间以及无脊椎动物源性吸入物与食物之间的反应。在此，我们概述了植物中最具临床相关性的泛变应原（肌动蛋白结合蛋白、钙结合蛋白、非特异性脂质转移蛋白、病程相关蛋白家族10成员）以及突出的动物源性泛变应原家族——原肌球蛋白。此外，我们探讨了泛变应原在过敏疾病致敏过程和进展中的作用。重点关注泛变应原致敏的流行病学方面和临床表现。最后，概述了与泛变应原致敏患者的诊断和治疗相关的问题，并讨论了将泛变应原用作交叉反应性过敏的预测指标和疾病严重程度的生物标志物的用途。
