Chopski Steven G, Fox Carson S, McKenna Kelli L, Riddle Michelle L, Kafagy Dhyaa H, Stevens Randy M, Throckmorton Amy L
BioCirc Research Laboratory, School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United States.
D. K. Engineering, Richmond, VA, United States.
Med Eng Phys. 2016 Jul;38(7):622-632. doi: 10.1016/j.medengphy.2016.03.010. Epub 2016 Apr 26.
Mechanical circulatory support offers an alternative therapeutic treatment for patients with dysfunctional single ventricle physiology. An intravascular axial flow pump is being developed as a cavopulmonary assist device for these patients. This study details the development of a new rotating impeller geometry. We examined the performance of 8 impeller geometries with blade stagger or twist angles varying from 100° to 800° using computational methods. A refined range of blade twist angles between 300° and 400° was then identified, and 4 additional geometries were evaluated. Generally, the impeller designs produced 4-26mmHg for flow rates of 1-4L/min for 6000-8000 RPM. A data regression analysis was completed and found the impeller with 400° of blade twist to be the superior performer. A hydraulic test was conducted on a prototype of the 400° impeller, which generated measurable pressure rises of 7-28mmHg for flow rates of 1-4L/min at 6000-8000 RPM. The findings of the numerical model and experiment were in reasonable agreement within approximately 20%. These results support the continued development of an axial-flow, mechanical cavopulmonary assist device as a new clinical therapeutic option for Fontan patients.
机械循环支持为单心室功能障碍生理患者提供了一种替代治疗方法。一种血管内轴流泵正在被开发用作这些患者的腔肺辅助装置。本研究详细介绍了一种新型旋转叶轮几何形状的开发。我们使用计算方法研究了8种叶轮几何形状的性能，其叶片交错角或扭转角在100°至800°之间变化。然后确定了300°至400°之间更精细的叶片扭转角范围，并评估了另外4种几何形状。一般来说，对于6000 - 8000转/分钟的转速，叶轮设计在1 - 4升/分钟的流速下产生4 - 26毫米汞柱的压力。完成了数据回归分析，发现叶片扭转角为400°的叶轮性能最佳。对400°叶轮的原型进行了水力测试，在6000 - 8000转/分钟的转速下，对于1 - 4升/分钟的流速，该测试产生了7 - 28毫米汞柱的可测量压力升高。数值模型和实验的结果在大约20%的范围内具有合理的一致性。这些结果支持继续开发一种轴流机械腔肺辅助装置，作为Fontan患者的一种新的临床治疗选择。
