Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, Virginia, USA.
ASAIO J. 2010 Jan-Feb;56(1):17-23. doi: 10.1097/MAT.0b013e3181c5b046.
To provide hemodynamic support to patients with a failing single ventricle, we are developing a percutaneously inserted, magnetically levitated axial flow blood pump designed to augment pressure in the cavopulmonary circulation. The device is designed to serve as a bridge-to-transplant, bridge-to-recovery, bridge-to-hemodynamic stability, or bridge-to-surgical reconstruction. This study evaluated the hydraulic performance of three blood pump prototypes (a four-bladed impeller, a three-bladed impeller, and a three-bladed impeller with a four-bladed diffuser) whose designs evolved from previous design optimization phases. Each prototype included the same geometric protective cage of filaments, which stabilize the rotor within the housing and protect the housing wall from the rotating blades. All prototypes delivered pressure rises over a range of flow rates and rotational speeds that would be sufficient to augment hemodynamic conditions in the cavopulmonary circulation. The four-bladed impeller outperformed the two remaining prototypes by >40%; this design was able to generate a pressure rise of 4-28 mm Hg for flow rates of 0.5-10 L/min at rotational speeds of 4,000-7,000 RPM. Successful development of this blood pump will provide clinicians with a feasible therapeutic option for mechanically supporting the failing Fontan.
为了给单心室功能衰竭的患者提供血液动力学支持，我们正在开发一种经皮插入的、磁悬浮轴向血流泵，旨在增加腔肺循环的压力。该设备旨在作为移植桥、恢复桥、血液动力学稳定桥或手术重建桥。本研究评估了三个血泵原型的水力性能（四叶叶轮、三叶叶轮和带四叶扩散器的三叶叶轮），其设计是从以前的设计优化阶段演变而来。每个原型都包括相同的几何保护纤维笼，该纤维笼可稳定转子在外壳内的位置，并保护外壳壁免受旋转叶片的影响。所有原型在一系列流量和转速范围内都能产生足够的压力升高，以增强腔肺循环的血液动力学条件。四叶叶轮比其余两个原型高出>40%；这种设计能够在 4000-7000 RPM 的转速下，在 0.5-10 L/min 的流量下产生 4-28 mmHg 的压力升高。这种血泵的成功开发将为临床医生提供一种可行的治疗选择，以机械方式支持衰竭的 Fontan。
