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[听觉脑干反应]

[The auditory brainstem response].

作者信息

Mochizuki Y

出版信息

No To Hattatsu. 1989 Mar;21(2):121-7.

PMID:2713155
Abstract

In 1967, Sohmer and Feinmesser recorded four negative peaks from extracochlear surface electrodes and they stated that the later components may be due to repetitive firing of auditory nerve fibers or may be due to the discharge of neurons in brain stem auditory nuclei. In 1970, Jewett, Romano and Williston presented the first full description of the scalp responses, postulated to be generated by brainstem nuclei. Since then, the auditory brainstem response (ABR) technique has attracted attention because it satisfied two previously unattainable needs; 1) a means of quantitative measurement of changes in auditory function in newborn babies or uncooperative patients, and 2) the detection of brainstem neurological abnormalities. Recording during wakefulness and in sleep or under drug intoxication has shown that ABRs are independent of the level of arousal or attention, and this feature is particularly useful for people unable to cooperate appropriately. Because of the close relationship to the anatomy of brainstem pathways, ABRs offer a neurophysiological index of neuronal function at the level of the brainstem. At present, these responses have become widely recognized as an important tool for the diagnosis of neurological diseases. One specific feature of the ABR is its dependence on maturation. The ABR appears at around 26 weeks of gestation and thereafter undergoes systematic changes in latency, amplitude and threshold. By using a supramaximal intensity of more than 60 dBHL, it is possible to evoke in all newborn babies with sufficient hearing ability, waves I, III and V.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

1967年,索默尔和费因梅塞尔从耳蜗外表面电极记录到四个负峰,他们指出,较晚出现的成分可能是由于听神经纤维的重复放电,也可能是由于脑干听觉核中的神经元放电。1970年,朱伊特、罗曼诺和威利斯顿首次全面描述了头皮反应,推测其由脑干核产生。从那时起,听觉脑干反应(ABR)技术就引起了关注,因为它满足了两个以前无法实现的需求:1)一种定量测量新生儿或不合作患者听觉功能变化的方法,2)检测脑干神经异常。在清醒、睡眠或药物中毒状态下进行记录表明,ABR与觉醒或注意力水平无关,这一特性对无法适当配合的人特别有用。由于与脑干通路的解剖结构密切相关,ABR提供了脑干水平神经元功能的神经生理学指标。目前,这些反应已被广泛认为是诊断神经疾病的重要工具。ABR的一个特定特征是其对成熟度的依赖性。ABR在妊娠约26周时出现,此后潜伏期、波幅和阈值会发生系统性变化。通过使用超过60 dBHL的超强强度,可以在所有听力足够的新生儿中引出I、III和V波。(摘要截取自250词)

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