Rotteveel J J, de Graaf R, Colon E J, Stegeman D F, Visco Y M
Hear Res. 1987;26(1):21-35. doi: 10.1016/0378-5955(87)90033-5.
Auditory evoked brainstem responses (ABRs) were recorded in 65 preterm infants (serially in 55 of them), divided into 5 groups, according to their gestational age (GA). The recording sessions were performed at 8 conceptional age levels (CA = GA + chronological age), of which the last two were about 40 and 52 weeks CA. The number of recording sessions varied from one to seven. A full set of ABR latency and amplitude parameters was analyzed including peaks I, II, IIN, III, V and IIc, IIINc and Vc as well as some interpeak latency differences (IPLDs), and the amplitude ratios. The detectability of the different components in the ABR tests at 70 dB reached 80-100% at about 32 weeks CA. The side of stimulation nor the state of vigilance influences the detectability. The degree of prematurity in the 5 GA groups did not influence the development of the parameters. Neither the side of stimulation nor generally the state of vigilance give rise to different parameter values. The thresholds show an age dependent decrease, which is also determined by central maturation. The differential development of the latency decrease of the ABR parameters with increasing conceptional age can be associated with morphological maturational processes and may add weight to the arguments in the delineation of the sources of the ABR. The ipsi- and contralateral central conduction V-II and Vc-IIc do not show latency differences at any CA level. The components IIc and Vc, however, lagged behind in absolute latency compared with II and V. It is concluded that the ABR is a powerful instrument for the study of the maturation of the human auditory pathway in the brainstem. In view of the variability, the detectability and the complex changes within the ABR during the preterm period, its application for clinical purposes during this period has a limited value.
对65名早产儿（其中55名进行了连续记录）进行了听觉诱发电位脑干反应（ABR）记录，根据胎龄（GA）将其分为5组。记录在8个孕龄水平（CA = GA + 实际年龄）进行，其中最后两个约为40和52周CA。记录次数从1次到7次不等。分析了全套ABR潜伏期和波幅参数，包括波峰I、II、IIN、III、V和IIc、IIINc和Vc以及一些峰间潜伏期差异（IPLD）和波幅比。在约32周CA时，70 dB的ABR测试中不同成分的可检测率达到80 - 100%。刺激侧和警觉状态均不影响可检测率。5个GA组的早产程度不影响参数的发育。刺激侧和一般的警觉状态均不会导致不同的参数值。阈值呈现年龄依赖性下降，这也由中枢成熟决定。随着孕龄增加，ABR参数潜伏期下降的差异发展可能与形态学成熟过程相关，并且可能为ABR来源的界定提供更多依据。同侧和对侧中枢传导V - II和Vc - IIc在任何CA水平均未显示潜伏期差异。然而，成分IIc和Vc在绝对潜伏期上比II和V滞后。结论是ABR是研究脑干中人类听觉通路成熟的有力工具。鉴于早产期间ABR的变异性、可检测性和复杂变化，在此期间将其应用于临床目的价值有限。
