Hughes R G, Colquhoun M, Eccles D M, Alloub M, Parker A C, Norval M, Smart G E
Lothian Area Colposcopy Clinic, Elsie Inglis Maternity Hospital, Edinburgh, UK.
Br J Cancer. 1989 Apr;59(4):594-9. doi: 10.1038/bjc.1989.120.
Twenty-seven patients with Hodgkin's (n = 19) and non-Hodgkin's (n = 8) lymphomas underwent cytological and colposcopic screening of the uterine cervix. Colposcopically directed cervical punch biopsies were taken from all patients in whom a colposcopic abnormality was detected. Lymphoma patients were compared with 79 controls with normal cervical cytology and no known haematological abnormality. Colposcopically directed punch biopsies were taken from the cervical transformation zone of all controls. Significantly more lymphoma patients (19%) than controls (3%) had CIN II or III (P less than 0.01) and cervical human papillomavirus infection, as judged by the presence of koilocytes (52% of lymphoma patients; 27% of controls; P less than 0.02). All six lymphoma patients with CIN had Hodgkin's disease (HD), and five had received combination chemotherapy. Half of the cases of CIN in lymphoma patients and all the cases of CIN in control patients were not detected by cervical cytology. This study suggests that female patients with HD are at increased risk of CIN, and that cervical cytology alone may be an inadequate form of screening for these patients.
27例霍奇金淋巴瘤（n = 19）和非霍奇金淋巴瘤（n = 8）患者接受了宫颈细胞学和阴道镜检查。对所有检测到阴道镜异常的患者进行了阴道镜引导下的宫颈活检。将淋巴瘤患者与79例宫颈细胞学正常且无已知血液学异常的对照者进行比较。对所有对照者的宫颈转化区进行了阴道镜引导下的活检。淋巴瘤患者中CIN II或III（P<0.01）以及宫颈人乳头瘤病毒感染（根据挖空细胞的存在判断，淋巴瘤患者为52%；对照者为27%；P<0.02）的比例显著高于对照者（分别为19%和3%）。所有6例患有CIN的淋巴瘤患者均为霍奇金病（HD），其中5例接受过联合化疗。淋巴瘤患者中一半的CIN病例以及对照患者中所有的CIN病例均未通过宫颈细胞学检查发现。本研究表明，HD女性患者患CIN的风险增加，且仅宫颈细胞学检查可能不足以对这些患者进行筛查。
