Tester W J, Kinsella T J, Waller B, Makuch R W, Kelley P A, Glatstein E, DeVita V T
J Clin Oncol. 1984 Jul;2(7):762-9. doi: 10.1200/JCO.1984.2.7.762.
The medical records of all patients treated for Hodgkin's disease during the years 1964-1981 were reviewed. Four hundred seventy-three previously untreated patients were analyzed. Thirty-four subsequent second malignant neoplasms were observed in 33 patients among those treated for Hodgkin's disease. Eight cases of acute nonlymphocyctic leukemia, one case of chronic myeloid leukemia, three cases of non-Hodgkin's lymphoma, three cases of sarcoma, and 19 other tumors were identified. The ten-year estimated risk of leukemia by treatment was the following: radiotherapy only (0), chemotherapy only (0.02), initial combined radiotherapy-chemotherapy (0.06), and salvage combined radiotherapy-chemotherapy (0.09). The ten-year estimated risk of solid tumors was 0.07 overall, with all treatment groups associated with similar risks. Unlike some other reports, a greater risk of leukemia in patients who began treatment for Hodgkin's disease at age 40 or older was not found. However, a positive association was noted between increasing risk of solid tumors and increasing patient age.
回顾了1964年至1981年间所有接受霍奇金病治疗的患者的病历。对473例未经治疗的患者进行了分析。在接受霍奇金病治疗的患者中，33例患者出现了34例后续的第二原发性恶性肿瘤。确定了8例急性非淋巴细胞白血病、1例慢性粒细胞白血病、3例非霍奇金淋巴瘤、3例肉瘤和19例其他肿瘤。按治疗方法计算的十年白血病估计风险如下：仅放疗（0）、仅化疗（0.02）、初始放化疗联合（0.06）和挽救性放化疗联合（0.09）。实体瘤的十年估计风险总体为0.07，所有治疗组的风险相似。与其他一些报告不同，未发现40岁及以上开始治疗霍奇金病的患者患白血病的风险更高。然而，实体瘤风险增加与患者年龄增加之间存在正相关。
