Lever L, Marks R
Department of Medicine (Dermatology), University of Wales College of Medicine, Heath Park, Cardiff, U.K.
Br J Dermatol. 1989 Mar;120(3):383-9. doi: 10.1111/j.1365-2133.1989.tb04164.x.
Fifty-two lesions of solar keratosis from 40 patients were studied prospectively for the presence of Darier-like changes and acantholysis. Twenty-seven per cent of specimens showed some degree of these changes. The affected lesions tended to be larger and were less common on the hands, but were otherwise clinically indistinguishable from other solar keratoses. Histologically, the specimens with Darier-like changes were significantly thicker and more dysplastic. The autoradiographic labelling index was not different for the lesions with these changes indicating similar cell kinetic characteristics. It is suggested that acantholytic separation of epidermal cells within a solar keratosis may signify that the lesion has a greater invasive potential than a solar keratosis not showing this change.
对40例患者的52处日光性角化病损害进行了前瞻性研究，以观察其是否存在达里埃样改变和棘层松解。27%的标本显示出一定程度的这些改变。受累损害往往更大，在手部较少见，但在其他方面临床上与其他日光性角化病无法区分。组织学上，具有达里埃样改变的标本明显更厚且发育异常更明显。有这些改变的损害的放射自显影标记指数没有差异，表明细胞动力学特征相似。提示日光性角化病内表皮细胞的棘层松解分离可能意味着该损害比未显示此改变的日光性角化病具有更大的侵袭潜能。
