Andreevscaia Olga, Theate Ivan, Goossens Cathy, Vanhooteghem Olivier
Department of Dermatology, St. Elisabeth Hospital , Namur, Belgium.
Department of Pathology, Institut de Pathologie et de Génétique , Gosselies, Belgium.
Rare Tumors. 2016 Mar 31;8(1):5713. doi: 10.4081/rt.2016.5713. eCollection 2016 Mar 21.
Desmoplastic melanoma (DM) is a rare variant of spindle-cell malignant melanoma. DM is easily misdiagnosed at an early stage because it can be confused with benign entities. Histological analysis, including careful attention to the presence of atypical spindle cells, as well as to lymphocytic aggregates in an abundant fibrotic stroma in the dermis, provides clues for diagnosis. The adjunction of an immunohistochemical panel, and particularly testing for S-100 protein, is needed for the final diagnosis.
促纤维增生性黑色素瘤（DM）是梭形细胞恶性黑色素瘤的一种罕见变体。DM在早期很容易被误诊，因为它可能与良性病变相混淆。组织学分析，包括仔细关注非典型梭形细胞的存在以及真皮中丰富纤维性基质中的淋巴细胞聚集情况，可为诊断提供线索。最终诊断需要联合免疫组织化学检测，尤其是S-100蛋白检测。
