Baranyai Zsolt, Jósa Valéria, Tóth Ambrus, Szilasi Zsuzsanna, Tihanyi Balazs, Zaránd Attila, Harsanyi Laszlo, Szállási Zoltán
a Department of Surgery , Semmelweis University Budapest , Hungary.
b Department of Otorhinolaryngology and Head and Neck Surgery, Flór Ferenc Hospital , Kistarcsa , Hungary.
Platelets. 2016 Jun;27(4):269-75. doi: 10.3109/09537104.2016.1170112. Epub 2016 May 2.
It has been demonstrated recently in several solid tumors that thrombocytosis at diagnosis may correlate with tumor invasion, metastatic progression and worse outcome. Several details of the pathomechanism of the relationship of thrombocytosis and cancer have been elucidated; however, the complete process is not clearly understood. Several hypotheses have been proposed. Recently, it was suggested that in ovarian cancer elevated IL-6 production by the tumor may induce increased megakaryopoiesis via hepatic thrombopoietin production leading to thrombocytosis. The importance of the prognostic power of elevated platelet count is still debated in gastrointestinal cancer. The aims of this review were to evaluate the prognostic significance of thrombocytosis in gastrointestinal tumors, to see whether clinical practice confirmed the hypotheses and to reveal the causes of the inconsistent findings.
最近在几种实体瘤中已证实，诊断时的血小板增多症可能与肿瘤侵袭、转移进展及较差的预后相关。血小板增多症与癌症关系的病理机制的一些细节已得到阐明；然而，整个过程尚未完全明了。已经提出了几种假说。最近，有人提出在卵巢癌中，肿瘤产生的白细胞介素-6升高可能通过肝脏产生血小板生成素诱导巨核细胞生成增加，从而导致血小板增多症。血小板计数升高的预后价值在胃肠道癌中仍存在争议。本综述的目的是评估血小板增多症在胃肠道肿瘤中的预后意义，观察临床实践是否证实了这些假说，并揭示结果不一致的原因。
