[阿片类药物治疗期间的继发性肾上腺功能不全]
[Secondary adrenal insufficiency during opiate treatment].
作者信息
Kornholt Jonatan
出版信息
Ugeskr Laeger. 2016 Apr 25;178(17).
PMID:27136952
Abstract
A 25-year-old previously healthy man developed secondary adrenal insufficiency during opiate treatment with tramadol and morphine for upper back pain. He experienced a 10 kg weight loss in six weeks. MRI of the hypothalamus and the pituitary gland ruled out cerebral pathology. After discontinuation of the opiate treatment the condition normalised. Opiate therapy can cause endocrine dysfunction, and clinicians should always consider adverse drug reactions as a differential diagnosis for unexplained symptoms.
摘要
一名25岁既往健康的男性在使用曲马多和吗啡治疗上背部疼痛的阿片类药物治疗期间出现继发性肾上腺功能不全。他在六周内体重减轻了10公斤。下丘脑和垂体的MRI排除了脑部病变。停用阿片类药物治疗后病情恢复正常。阿片类药物治疗可导致内分泌功能障碍，临床医生应始终将药物不良反应作为不明原因症状的鉴别诊断考虑因素。
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