Guilbaud G, Benoist J M, Eschalier A, Kayser V, Gautron M, Attal N
Unité de Recherche en Physiopharmacologie du Système nerveux U 161 INSERM, Paris, France.
Brain Res. 1989 Apr 10;484(1-2):383-8. doi: 10.1016/0006-8993(89)90386-7.
In this study performed in the Freund's adjuvant-induced arthritic rat, a local injection of lidocaine in one hind paw strongly depressed the ventrobasal thalamic neuronal responses to mild stimulation of both ankles. In parallel, a behavioral study provided evidence for a bilateral hypoalgesia, tested by the vocalization threshold to paw pressure, after a unilateral anesthetic block. The involvement of central phenomena in the changes of neuronal responsivity described in this model of experimental pain is therefore suggested.
在这项针对弗氏佐剂诱导的关节炎大鼠进行的研究中，在一只后爪局部注射利多卡因，强烈抑制了丘脑腹侧基底核神经元对双侧踝关节轻度刺激的反应。同时，一项行为学研究提供了证据，表明在单侧麻醉阻滞之后，通过对爪部压力的发声阈值测试发现存在双侧痛觉减退。因此，提示在该实验性疼痛模型中所描述的神经元反应性变化涉及中枢现象。
