Yakovleff A, Roby-Brami A, Guezard B, Mansour H, Bussel B, Privat A
INSERM U. 215, Hôpital Raymond Poincaré, Garches, France.
Brain Res Bull. 1989 Jan;22(1):115-21. doi: 10.1016/0361-9230(89)90135-4.
It is known that catecholaminergic drugs can induce both locomotion and a late flexion reflex in spinalized animals. We studied spinal reflexes and locomotor activity in five adult spinal rats which had received a suspension of fetal noradrenergic (NA) neurons below the transection and in three control spinal rats. A rhythmical activity similar to the one of locomotion was regularly observed in three of the grafted rats held above a moving belt. In two of them, the step frequency was increased when the velocity of the moving belt was increased. This was not observed in control rats. A late flexion reflex was obtained in grafted rats that displayed locomotor activity, as well as in two controls. In the two rats which exhibited locomotor activity, analysis showed numerous immunoreactivite (against NA) cells and processes with terminals concentrated around the perikarya of motoneurones.
已知儿茶酚胺能药物可在脊髓动物中诱导运动和晚期屈曲反射。我们研究了五只成年脊髓大鼠的脊髓反射和运动活动，这些大鼠在横断下方接受了胎儿去甲肾上腺素能（NA）神经元悬液移植，还研究了三只对照脊髓大鼠。在三只置于移动带上方的移植大鼠中，定期观察到一种类似于运动的节律性活动。其中两只大鼠，当移动带速度增加时，步频也增加。对照大鼠中未观察到此现象。在表现出运动活动的移植大鼠以及两只对照大鼠中均获得了晚期屈曲反射。在两只表现出运动活动的大鼠中，分析显示有大量免疫反应性（抗NA）细胞和突起，其终末集中在运动神经元胞体周围。
