Signorile Pietro Giulio, Baldi Alfonso
Centro Italiano Endometriosi, Rome, Italy.
J Cell Physiol. 2016 Dec;231(12):2622-7. doi: 10.1002/jcp.25410. Epub 2016 May 16.
Endometriosis is a very common disease, affecting 10% of women in the reproductive age. To date, a significant delay between onset of the symptoms and definitive diagnosis is caused by the lack of a reliable non-invasive diagnostic test. Recently, the potential value as diagnostic markers for endometriosis of three proteins (Zn-alpha2-glycoprotein, serum albumin, and complement C3 precursor), has been showed. In this article, we have defined the experimental conditions for the development of a multiplex bead array assay for rapid and simultaneous quantification of these three biomarkers in the serum of patients with endometriosis. Finally, pivotal experiments on a small cohort of patients have confirmed the diagnostic value of this assay. J. Cell. Physiol. 231: 2622-2627, 2016. © 2016 Wiley Periodicals, Inc.
子宫内膜异位症是一种非常常见的疾病，影响着10%的育龄女性。迄今为止，由于缺乏可靠的非侵入性诊断测试，症状出现与最终确诊之间存在显著延迟。最近，三种蛋白质（锌-α2-糖蛋白、血清白蛋白和补体C3前体）作为子宫内膜异位症诊断标志物的潜在价值已得到证实。在本文中，我们确定了用于开发多重微珠阵列分析的实验条件，以快速同时定量子宫内膜异位症患者血清中的这三种生物标志物。最后，对一小群患者进行的关键实验证实了该分析的诊断价值。《细胞生理学杂志》231: 2622 - 2627, 2016年。© 2016威利期刊公司。
