Department of Chemistry, National University of Singapore , 3 Science Drive 3, Republic of Singapore 117543.
J Am Chem Soc. 2016 May 25;138(20):6571-6. doi: 10.1021/jacs.6b02372. Epub 2016 May 13.
We present here an unprecedented cobalt-catalyzed enantioselective vinylation of α-ketoesters, isatins, and imines to deliver a range of synthetically useful allylic alcohols and amines in high enantiopurity. This method employs commercially available and easy to handle catalysts and reagents and exhibits a high degree of practicality. The efficiency, selectivity, and operational simplicity of this catalytic system coupled with the substrate generality render this method a valuable tool in organic synthesis.
我们在此展示了一种前所未有的钴催化的对映选择性α-酮酯、色酮和亚胺的乙烯基化反应，以高对映纯度得到一系列具有合成用途的烯丙醇和胺。该方法使用商业上可获得且易于处理的催化剂和试剂，具有高度的实用性。该催化体系的效率、选择性和操作简单性以及底物通用性使其成为有机合成中的一种有价值的工具。
