McGrath D J, O'Brien B, Bruzzi M, Kelly N, Clauser J, Steinseifer U, McHugh P E
Biomechanics Research Centre (BMEC), Biomedical Engineering, College of Engineering and Informatics, NUI Galway, Ireland.
Biomechanics Research Centre (BMEC), Biomedical Engineering, College of Engineering and Informatics, NUI Galway, Ireland.
J Mech Behav Biomed Mater. 2016 Aug;61:567-580. doi: 10.1016/j.jmbbm.2016.04.023. Epub 2016 Apr 22.
Covered tracheobronchial stents are used to prevent tumour growth from reoccluding the airways. In the present work a combination of experimental and computational methods are used to present the mechanical effects that adhered covers can have on stent performance. A prototype tracheobronchial stent is characterised in bare and covered configurations using radial force, flat plate and a novel non-uniform radial force test, while computational modelling is performed in parallel to extensively inform the physical testing. Results of the study show that cover configuration can have a significant structural effect on stent performance, and that stent response (bare or covered) is especially loading specific, highlighting that the loading configuration that a stent is about to be subjected to should be considered before stent implantation.
覆膜气管支气管支架用于防止肿瘤生长导致气道再次阻塞。在本研究中,采用实验和计算方法相结合的方式,来呈现附着的覆膜对支架性能可能产生的力学效应。使用径向力、平板和一种新型非均匀径向力测试对原型气管支气管支架的裸支架和覆膜支架构型进行表征,同时并行进行计算建模以全面辅助物理测试。研究结果表明,覆膜构型对支架性能会产生显著的结构影响,并且支架的响应(裸支架或覆膜支架)具有特定的载荷依赖性,这突出表明在支架植入前应考虑支架即将承受的载荷构型。