Forsyth Rob, Martland Tim, Lai Ming, Vadlamani Gayatri, Hogan Vanessa
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE1 7RU, UK; Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle NE1 4LP, UK.
Department of Paediatric Neurology, Royal Manchester Children's Hospital, Oxford Road, Manchester M13 9WL, UK.
Eur J Paediatr Neurol. 2016 Jul;20(4):560-5. doi: 10.1016/j.ejpn.2016.04.001. Epub 2016 Apr 22.
To establish the efficacy and tolerability of inhaled 5% carbon dioxide/95% oxygen as a treatment for paediatric non-convulsive status epilepticus (NCSE).
In an open label clinical trial, children in NCSE were given high flow inhaled 5% carbon dioxide/95% oxygen by face mask for 120 s under EEG control.
Six children (five male; ages 3-13; all with severe underlying epilepsy and disability) were recruited. Inhalation was well tolerated in all cases. Capillary blood gasses showed no significant derangements at the end of the inhalation. Effects on EEG normalisation were limited and transient, and no clinical improvements were noted. No adverse effects occurred.
Inhaled 5% carbon dioxide/95% oxygen has been suggested as a potent, well tolerated anticonvulsant. An anticonvulsant without sedating and respiration-depressing effects would be particularly welcome in the management of NCSE where the justification for aggressive anticonvulsant therapy is often uncertain, however it appears that 5% carbon dioxide is of limited efficacy in this context.
确定吸入5%二氧化碳/95%氧气治疗小儿非惊厥性癫痫持续状态（NCSE）的疗效和耐受性。
在一项开放标签临床试验中，对处于NCSE状态的儿童在脑电图监测下通过面罩给予高流量吸入5%二氧化碳/95%氧气，持续120秒。
招募了6名儿童（5名男性；年龄3 - 13岁；均患有严重的潜在癫痫和残疾）。所有病例对吸入耐受性良好。吸入结束时毛细血管血气未见明显紊乱。对脑电图恢复正常的作用有限且短暂，未观察到临床改善。未发生不良反应。
吸入5%二氧化碳/95%氧气被认为是一种强效且耐受性良好的抗惊厥药。在NCSE的治疗中，一种无镇静和呼吸抑制作用的抗惊厥药会特别受欢迎，因为在NCSE中积极抗惊厥治疗的合理性往往不确定，然而在这种情况下5%二氧化碳似乎疗效有限。
