Department of Orthopaedics and Traumatology, Konya Training and Research Hospital, Konya-Turkey.
Department of Orthopaedics and Traumatology, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale-Turkey.
Ulus Travma Acil Cerrahi Derg. 2022 Apr;28(4):411-417. doi: 10.14744/tjtes.2021.02575.
Bone fractures and fracture healing are one of the most common problems among orthopedic surgeons. In this study, we investigated the effects of hyperbaric oxygen (HBO) and carbogen (C) treatment on fracture healing in the experimental animal model.
Twenty-four male Wistar-Albino rats were randomly divided into three groups as Group 1 (C inhalation therapy), Group 2 (HBO inhalation therapy), and Group 3 (control group), with eight rats in each group. HBO and C treatment were given to the rats in Group 1 and Group 2 1 week before the surgical procedure and 3 weeks after the surgical procedure. Following the surgical procedure, all rats were killed at the end of the 3rd week and the healing tissue in the fracture line was evaluated clinically, radiologically, and histopathologically.
Although there were higher histopathological, radiological, and clinical scores in the HBO and C groups in terms of frac-ture healing compared to the control group, there was no statistically significant difference between the groups.
There are many studies in the literature that examine the systemic and local effects of HBO and C treatments and show that they increase tissue oxygenation. Our study showed that HBO and C groups had no beneficial or harmful effects on fracture healing compared to the control group.
骨折及骨折愈合是骨科医生最常面临的问题之一。本研究通过实验动物模型，探讨高压氧（HBO）和碳氧混合气（C）治疗对骨折愈合的影响。
24 只雄性 Wistar-Albino 大鼠随机分为三组，即 C 组（吸入 C 治疗）、HBO 组（吸入 HBO 治疗）和对照组（每组 8 只）。C 组和 HBO 组于手术前 1 周开始治疗，术后 3 周结束。术后 3 周，所有大鼠均被处死，通过临床、放射学和组织病理学评估骨折线愈合组织。
尽管 HBO 和 C 组在骨折愈合的组织病理学、放射学和临床评分方面均高于对照组，但组间无统计学差异。
文献中有许多研究检查了 HBO 和 C 治疗的全身和局部作用，表明它们可增加组织氧合。与对照组相比，本研究显示 HBO 和 C 组对骨折愈合无有益或有害影响。
