2周龄以上早产儿的咖啡因药代动力学
Caffeine pharmacokinetics in preterm infants older than 2 weeks.
作者信息
Pearlman S A, Duran C, Wood M A, Maisels M J, Berlin C M
机构信息
Department of Pediatrics, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.
出版信息
Dev Pharmacol Ther. 1989;12(2):65-9.
We studied 17 preterm infants receiving caffeine, and measured their plasma levels of caffeine and the theophylline metabolite by high-pressure liquid chromatography. The half-life was calculated by computer analysis using the least-square method. The mean gestational age of our patients was 29.7 +/- 1.9 weeks (mean +/- SD) and they were studied at 20.7 +/- 6.6 days (mean +/- SD) postnatal age. The caffeine half-life was 52.03 +/- 23.87 h (means +/- SD) and the theophylline half-life was 77.04 +/- 65.01 h (mean +/- SD).
我们研究了17名接受咖啡因治疗的早产儿，并通过高压液相色谱法测量了他们血浆中的咖啡因和茶碱代谢物水平。半衰期通过计算机分析使用最小二乘法计算得出。我们患者的平均胎龄为29.7±1.9周（平均值±标准差），且在出生后20.7±6.6天（平均值±标准差）进行研究。咖啡因半衰期为52.03±23.87小时（平均值±标准差），茶碱半衰期为77.04±65.01小时（平均值±标准差）。
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