Stile I L, Zolfaghari S, Hiatt I M, Hegyi T
Clin Ther. 1986;8(3):336-41.
The disposition of theophylline in premature infants on the first day of life was studied in nine preterm infants after intravenous administration of the drug. Theophylline concentrations in the blood were measured by means of high-pressure liquid chromatography. Theophylline's apparent volume of distribution (mean +/- SD) was 1.02 +/- 0.13 L/kg, a value similar to those previously reported, but the half-life (16.9 +/- 6.2 hr) was considerably shorter. The elimination rate constant (0.046 +/- 0.020/hr) and the clearance rate (46 +/- 14 ml/kg/hr) were faster than in older infants. Follow-up studies in three infants on the third day of life showed lower clearance rates than were obtained on the first day. The newborn preterm infants in this study eliminated theophylline at an unexpectedly rapid rate. Dosage calculations for therapy at this age should be based on these kinetic data.
在9名早产婴儿静脉注射药物后，对其出生第一天氨茶碱的处置情况进行了研究。通过高压液相色谱法测量血液中的氨茶碱浓度。氨茶碱的表观分布容积（平均值±标准差）为1.02±0.13L/kg，该值与先前报道的相似，但半衰期（16.9±6.2小时）明显更短。消除速率常数（0.046±0.020/小时）和清除率（46±14ml/kg/小时）比大龄婴儿更快。对3名婴儿出生第三天的随访研究显示，清除率低于第一天。本研究中的新生儿早产儿消除氨茶碱的速度出乎意料地快。这个年龄段治疗的剂量计算应基于这些动力学数据。
