Herman B H, Hammock M K, Egan J, Arthur-Smith A, Chatoor I, Werner A
Brain Research Center, George Washington University School of Medicine, Washington, D.C.
Dev Pharmacol Ther. 1989;12(2):81-9.
The effects of acute, orally administered naltrexone (0.5, 1.0, 1.5 and 2.0 mg/kg), a potent opioid receptor antagonist, on self-injurious behavior (SIB), heart rate, and blood pressure in three males (one 10-year-old and two 17-year-olds) were investigated. Subjects were evaluated in a structured test session for SIB. The frequency of the most predominant type of SIB (head and face hitting) was significantly reduced by naltrexone (maximum was 71% at the 1.5 mg/kg dose), while self-biting was not significantly decreased at any dose. In contrast, naltrexone had no significant effect on heart rate or blood pressure. Based upon these and other results it was concluded that naltrexone produced decreases in specific SIBs by blocking opioid receptors in brain, and that such opioid blockade had no effect on two measures of cardiovascular function.
研究了强效阿片受体拮抗剂纳曲酮（0.5、1.0、1.5和2.0毫克/千克）急性口服给药对三名男性（一名10岁和两名17岁）的自伤行为（SIB）、心率和血压的影响。在结构化测试环节对受试者的自伤行为进行评估。纳曲酮显著降低了最主要的自伤行为类型（头部和面部撞击）的频率（在1.5毫克/千克剂量时最大降幅为71%），而在任何剂量下自咬行为均未显著减少。相比之下，纳曲酮对心率或血压没有显著影响。基于这些及其他结果得出结论，纳曲酮通过阻断大脑中的阿片受体减少了特定的自伤行为，且这种阿片受体阻断对心血管功能的两项指标没有影响。
