Herman B H, Hammock M K, Arthur-Smith A, Egan J, Chatoor I, Werner A, Zelnik N
Brain Research Center, Children's Hospital National Medical Center, Washington, DC 20010.
Ann Neurol. 1987 Oct;22(4):550-2. doi: 10.1002/ana.410220419.
The effect of naltrexone (0.5, 1.0, 1.5, and 2.0 mg/kg) on the frequency of self-injurious behavior (SIB) was investigated in three male adolescents. The frequency of total SIB was reduced significantly in all three subjects; dose-dependent decreases (at 0.5, 1.0, and 1.5 mg/kg) in SIB frequency were observed in the two mentally retarded subjects. These data suggest a role for opioid peptides in SIB.
研究了纳曲酮（0.5、1.0、1.5和2.0毫克/千克）对三名男性青少年自我伤害行为（SIB）频率的影响。所有三名受试者的总SIB频率均显著降低；在两名智力迟钝的受试者中观察到SIB频率呈剂量依赖性降低（0.5、1.0和1.5毫克/千克）。这些数据表明阿片肽在SIB中起作用。
