人类精子发生及其影响因素。

Spermatogenesis in humans and its affecting factors.

机构信息

Center for Male Reproductive Medicine and Microsurgery, Department of Urology and Institute of Reproductive Medicine, Weill Cornell Medical College, New York, NY, United States.

出版信息

Semin Cell Dev Biol. 2016 Nov;59:10-26. doi: 10.1016/j.semcdb.2016.04.009. Epub 2016 Apr 30.

DOI:10.1016/j.semcdb.2016.04.009

PMID:27143445

Abstract

Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia into spermatozoa requires the participation of several cell types, hormones, paracrine factors, genes and epigenetic regulators. Recent researches in animals and humans have furthered our understanding of the male gamete differentiation, and led to clinical tools for the better management of male infertility. There is still much to be learned about this intricate process. In this review, the critical steps of human spermatogenesis are discussed together with its main affecting factors.

摘要

精子发生是一个极其复杂的过程。精原细胞分化为精子需要几种细胞类型、激素、旁分泌因子、基因和表观遗传调节剂的参与。动物和人类的最新研究进一步加深了我们对雄性配子分化的理解，并为更好地管理男性不育症提供了临床工具。关于这个复杂的过程，我们还有很多需要了解。在这篇综述中，讨论了人类精子发生的关键步骤及其主要影响因素。