与神经移植物相比，长神经构建体中的血管化延迟。
Vascularization is delayed in long nerve constructs compared with nerve grafts.
作者信息
Farber Scott J, Hoben Gwendolyn M, Hunter Daniel A, Yan Ying, Johnson Philip J, Mackinnon Susan E, Wood Matthew D
机构信息
Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, Campus Box 8238, 660 South Euclid Avenue, St. Louis, Missouri, 63110, USA.
出版信息
Muscle Nerve. 2016 Aug;54(2):319-21. doi: 10.1002/mus.25173. Epub 2016 May 27.
INTRODUCTION
Nerve regeneration across nerve constructs, such as acellular nerve allografts (ANAs), is inferior to nerve auto/isografts especially in the case of long defect lengths. Vascularization may contribute to poor regeneration. The time course of vascular perfusion within long grafts and constructs was tracked to determine vascularization.
METHODS
Male Lewis rat sciatic nerves were transected and repaired with 6 cm isografts or ANAs. At variable days following grafting, animals were perfused with Evans Blue albumin, and grafts were evaluated for vascular perfusion by a blinded observer.
RESULTS
Vascularization at mid-graft was re-established within 3-4 days in 6 cm isografts, while it was established after 10 days in 6 cm ANAs.
CONCLUSIONS
Vascular perfusion is reestablished over a shorter time course in long isografts when compared with long ANAs. The differences in vascularization of long ANAs compared with auto/isografts suggest regenerative outcomes across ANAs could be affected by vascularization rates. Muscle Nerve 54: 319-321, 2016.
引言
神经在神经构建物（如脱细胞神经同种异体移植物（ANA））上的再生能力不如神经自体/同基因移植，尤其是在缺损长度较长的情况下。血管化可能是导致再生不良的原因之一。对长移植物和构建物内血管灌注的时间进程进行追踪以确定血管化情况。
方法
将雄性Lewis大鼠的坐骨神经切断，并用6厘米的同基因移植物或ANA进行修复。在移植后的不同天数，用伊文思蓝白蛋白对动物进行灌注，由一位不知情的观察者对移植物的血管灌注情况进行评估。
结果
6厘米的同基因移植物在移植后3 - 4天内移植中间部位的血管化得以重建，而6厘米的ANA在10天后才建立血管化。
结论
与长ANA相比，长同基因移植物的血管灌注在更短的时间进程内得以重建。长ANA与自体/同基因移植物在血管化方面的差异表明，ANA的再生结果可能会受到血管化速率的影响。《肌肉与神经》54: 319 - 321, 2016年。
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