Department of Radiation Oncology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, BRB 325, Cleveland, OH 44106, USA.
Mol Cancer Res. 2011 May;9(5):538-44. doi: 10.1158/1541-7786.MCR-11-0065. Epub 2011 Mar 8.
Cellular senescence has emerged as a biological response to two major pathophysiological states of our being: cancer and aging. In the course of the transformation of a normal cell to a cancerous cell, senescence is frequently induced to suppress tumor development. In aged individuals, senescence is found in cells that have exhausted their replication potential. The similarity in these responses suggests that understanding how senescence is mediated can provide insight into both cancer and aging. One environmental factor that is implicated in both of these states is tissue hypoxia, which increases with aging and can inhibit senescence. Hypoxia is particularly important in normal physiology to maintain the stem cell niche; but at the same time, hypoxic inhibition of an essential tumor suppressor response can theoretically contribute to cancer initiation.
癌症和衰老。在正常细胞向癌细胞转化的过程中，衰老经常被诱导以抑制肿瘤的发展。在衰老的个体中，衰老发生在已经耗尽其复制潜力的细胞中。这些反应的相似性表明，了解衰老的调节机制可以深入了解癌症和衰老。与这两种状态都有关的一个环境因素是组织缺氧，随着年龄的增长，组织缺氧会增加，并可能抑制衰老。在正常生理中，缺氧对于维持干细胞生态位非常重要；但与此同时，缺氧抑制一个必要的肿瘤抑制反应在理论上可以促进癌症的发生。
