伏隔核深部脑刺激治疗酒精成瘾——一项试点试验的安全性及临床长期结果

Nucleus Accumbens Deep Brain Stimulation for Alcohol Addiction - Safety and Clinical Long-term Results of a Pilot Trial.

作者信息

Müller U J, Sturm V, Voges J, Heinze H-J, Galazky I, Büntjen L, Heldmann M, Frodl T, Steiner J, Bogerts B

机构信息

Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Magdeburg.

Department of Stereotaxy and Functional Neurosurgery, University of Cologne, Cologne.

出版信息

Pharmacopsychiatry. 2016 Jul;49(4):170-3. doi: 10.1055/s-0042-104507. Epub 2016 May 4.

DOI:10.1055/s-0042-104507

PMID:27145161

Abstract

We report on the long-term clinical outcome (up to 8 years) of 5 patients who received deep brain stimulation (DBS) of the nucleus accumbens to treat their long-lasting and treatment-resistant alcohol addiction. All patients reported a complete absence of craving for alcohol; 2 patients remained abstinent for many years and 3 patients showed a marked reduction of alcohol consumption. No severe or long-standing side effects occurred. Therefore, DBS could be a promising, novel treatment option for severe alcohol addiction, but larger clinical trials are needed to further investigate the efficacy of DBS in addiction.

摘要

我们报告了5例接受伏隔核深部脑刺激（DBS）治疗长期存在且难治性酒精成瘾患者的长期临床结果（长达8年）。所有患者均报告完全没有对酒精的渴望；2例患者多年保持戒酒，3例患者酒精摄入量显著减少。未出现严重或长期的副作用。因此，DBS可能是一种有前景的、针对严重酒精成瘾的新型治疗选择，但需要更大规模的临床试验来进一步研究DBS在成瘾治疗中的疗效。