Lee Jun Ho, Lee Sung Won
a Department of Urology , National Police Hospital , Seoul , Korea and.
b Department of Urology , Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine , Seoul , Korea.
Aging Male. 2016 Jun;19(2):106-10. doi: 10.3109/13685538.2016.1150993. Epub 2016 May 5.
We evaluated the impact of total prostate volume (TPV) on the international index of erectile function-5 (IIEF) and the premature ejaculation diagnostic tool (PEDT). A cross-sectional study was conducted that included 8336 men who had participated in a health examination. PEDT, IIEF and transrectal ultrasonography were used. A full metabolic work-up and serum testosterone level checks were also performed. The median age of participants was 51.0 years. In total, 40.1% had IIEF scores ≤16. Additionally, 24.7% were classified as demonstrating premature ejaculation (PE) (PEDT > 10). The severity of erectile dysfunction (ED) significantly increased with the TPV (p trend < 0.001). After adjusting for potential confounding factors, the odds ratio (OR) for IIEF scores ≤ 16 significantly increased in the group with TPVs of 30-39 cm(3) and the group with TPVs ≥ 40 cm(3) compared with the group with TPVs ≤ 19 cm(3) (TPV 30-39 cm(3), OR: 1.204, 95% confidence interval: 1.034-1.403; TPV ≥ 40 cm(3), OR: 1.326: 95% confidence interval: 1.051-1.733) and this relationship was maintained after adjusting for propensity score (TPV ≥ 30 cm(3), OR: 1.138: 95% confidence interval: 1.012-1.280). However, neither PEDT nor PE was correlated with TPV. In conclusion, TPV is significantly and independently correlated with IIEF but not with PEDT. Future investigations should explore the temporal relationship between TPV and ED.
我们评估了前列腺总体积（TPV）对国际勃起功能指数-5（IIEF）和早泄诊断工具（PEDT）的影响。开展了一项横断面研究，纳入了8336名参加健康体检的男性。使用了PEDT、IIEF和经直肠超声检查。还进行了全面的代谢检查和血清睾酮水平检测。参与者的中位年龄为51.0岁。总体而言，40.1%的参与者IIEF评分≤16。此外，24.7%被归类为患有早泄（PE）（PEDT＞10）。勃起功能障碍（ED）的严重程度随TPV显著增加（p趋势＜0.001）。在调整潜在混杂因素后，与TPV≤19 cm³的组相比，TPV为30 - 39 cm³的组和TPV≥40 cm³的组中IIEF评分≤16的比值比（OR）显著增加（TPV 30 - 39 cm³，OR：1.204，95%置信区间：1.034 - 1.403；TPV≥40 cm³，OR：1.326：95%置信区间：1.051 - 1.733），并且在调整倾向得分后这种关系仍然存在（TPV≥30 cm³，OR：1.138：95%置信区间：1.012 - 1.280）。然而，PEDT和PE均与TPV无关。总之，TPV与IIEF显著且独立相关，但与PEDT无关。未来的研究应探索TPV与ED之间的时间关系。
