Huang Yunxia, Hu Bing, Zhu Jiaan
Department of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, 600 Yishan Rd, Shanghai, 200233, China.
Department of Ultrasound, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, China.
Australas Phys Eng Sci Med. 2016 Dec;39(4):997-1005. doi: 10.1007/s13246-016-0448-8. Epub 2016 May 4.
Ultrasound is an effective tool for peripheral disease with direct imaging of morphological and echogenic changes, but it has limitations when applied to evaluation of diabetic peripheral neuropathy. The aim of this study was to assess the role of ultrasound to quantitatively evaluate diabetic peripheral neuropathy in rat sciatic nerve. In our experiments, ultrasound imaging and electrophysiological examination testing of sciatic nerves were monitored in diabetic and control rats at the period of 1st and 4th month of hyperglycemia. Cross sectional area, intraneural echo intensity, inner diameter, motor nerve conduction velocity, and histological changes were measured and compared between diabetic and control groups. Intraneural hyperechoic were observed in the diabetic rats, and the echo intensity of the sciatic nerve was increased in diabetic rats rather than control lean rats at 4th month of hyperglycemia (p < 0.05), which has shown a similar correlation with functional deficit and histological changes based on the severity of diabetic peripheral neuropathy. We conclude that the echo intensity is potentially useful in detecting diabetic peripheral neuropathy, which can pave the way for more accurate and efficient diagnosis in clinical study.
超声是用于外周疾病的一种有效工具，可直接成像形态学和回声变化，但在评估糖尿病性周围神经病变时存在局限性。本研究的目的是评估超声在定量评估大鼠坐骨神经糖尿病性周围神经病变中的作用。在我们的实验中，在高血糖第1个月和第4个月时，对糖尿病大鼠和对照大鼠的坐骨神经进行超声成像和电生理检查监测。测量并比较糖尿病组和对照组之间的横截面积、神经内回声强度、内径、运动神经传导速度和组织学变化。在糖尿病大鼠中观察到神经内高回声，在高血糖第4个月时，糖尿病大鼠坐骨神经的回声强度高于对照瘦鼠（p<0.05），这与基于糖尿病性周围神经病变严重程度的功能缺陷和组织学变化显示出相似的相关性。我们得出结论，回声强度在检测糖尿病性周围神经病变方面可能有用，这可为临床研究中更准确、高效的诊断铺平道路。
